ChloroquineV1, Main, Exploration, bibRecord, 000785

HPLC-DAD-SPE-NMR isolation of tetracyclic spiro-alkaloids with antiplasmodial activity from the seeds of Erythrina latissima.

Identifieur interne : 000785 ( Main/Exploration ); précédent : 000784; suivant : 000786

HPLC-DAD-SPE-NMR isolation of tetracyclic spiro-alkaloids with antiplasmodial activity from the seeds of Erythrina latissima.

Auteurs : Yancho Zarev [Belgique] ; Kenn Foubert [Belgique] ; Paul Cos [Belgique] ; Louis Maes [Belgique] ; Esameldin Elgorashi [Afrique du Sud] ; Sandra Apers [Belgique] ; Iliana Ionkova [Bulgarie] ; Luc Pieters [Belgique]

Source :

Natural product research [ 1478-6427 ] ; 2019.

RBID : pubmed:30602319

Abstract

Seven tetracyclic spiro-alkaloids, i.e. glucoerysodine (1), erysodine (2), epi-erythratidine (3), erysovine (4), erythratidine (5), erysotrine (6) and erythraline (7) were isolated from the seeds of Erythrina latissima by means of conventional separation methods and HPLC-DAD-SPE-NMR. Their structures were elucidated by spectroscopic means. This is the first report on the isolation of compounds 3, 5 and 6 from this plant. Antiplasmodial activity against the chloroquine-resistant strain Plasmodium falciparum K1 and cytotoxicity against MRC-5 cells (human fetal lung fibroblast cells) was assessed in vitro. Erysodine (2) and erysovine (4) showed moderate activity (IC₅₀ 6.53 µM and 4.05 µM, respectively), compared with the standard chloroquine (IC₅₀ = 0.14 µM). No cytotoxicity was observed in a concentration up to 64.0 µM.

DOI: 10.1080/14786419.2018.1539976
PubMed: 30602319

Affiliations:

Afrique du Sud, Belgique, Bulgarie

Le document en format XML

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<front><div type="abstract" xml:lang="en">Seven tetracyclic spiro-alkaloids, i.e. glucoerysodine (1), erysodine (2), epi-erythratidine (3), erysovine (4), erythratidine (5), erysotrine (6) and erythraline (7) were isolated from the seeds of Erythrina latissima by means of conventional separation methods and HPLC-DAD-SPE-NMR. Their structures were elucidated by spectroscopic means. This is the first report on the isolation of compounds 3, 5 and 6 from this plant. Antiplasmodial activity against the chloroquine-resistant strain Plasmodium falciparum K1 and cytotoxicity against MRC-5 cells (human fetal lung fibroblast cells) was assessed in vitro. Erysodine (2) and erysovine (4) showed moderate activity (IC<sub>50</sub>
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HPLC-DAD-SPE-NMR isolation of tetracyclic spiro-alkaloids with antiplasmodial activity from the seeds of Erythrina latissima.

HPLC-DAD-SPE-NMR isolation of tetracyclic spiro-alkaloids with antiplasmodial activity from the seeds of Erythrina latissima.

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